ED Free

Urology formulations include Trimix-L for patients with erectile dysfunction.

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There are more than 600,000 new cases of erectile dysfunction in the United States expected annually of men ages 40-69.1

doctor imageErectile dysfunction, also known as impotence, is a condition that occurs mainly in men over the age of 40 and the incidence rate can increase with age as well as current or risk of underlying conditions.1,2 According to a study, up to 15% of men by age 70 experience complete impotence.2

Treatments for ED

According to the AUA Guidelines, men who are diagnosed with ED may be put on the following treatments:

  • Oral Phosphodiesterase Type 5 (PDE5) Inhibitors
  • Alprostadil Intra-urethral Suppositories
  • Intracavernous Drug Injection Therapy (BimixTrimix, etc)
  • Vacuum Constriction Devices
  • Penile Prosthesis Implantation
  • Vascular Surgery

Lyophilized Compounded Formulations

Tri-Mix-L* (phentolamine, papaverine, and prostaglandin), a lyophilized compounded formulation is provided in a sterile powder for injection within single dose vials that may last up to 6 months prior to reconstitution. Once reconstituted, it should be used immediately.

Example formulations include:

  • Tri-Mix* I

    Phentolamine 0.5mg / Papaverine 10mg / Prostaglandin E1 5mcg
    0.5mL single use vial

  • Tri-Mix* II

    Phentolamine 1mg / Papaverine 15mg / Prostaglandin E1 10mcg
    0.5mL single use vial

  • Tri-Mix* III

    Phentolamine 1mg / Papaverine 15mg / Prostaglandin E1 20mcg
    0.5mL single use vial

Each lyophilized kit of Tri-Mix includes 10 single dose vials and provides:

  • Portability of the formulation stored at room temperature
  • Convenience of proper dosing in single dose vials
  • Improvement of patient experience

Intracavernous injections including Trimix have been identified as the most effective non-surgical treatment for patients with erectile dysfunction.3

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*Compounded by a pharmacist pursuant to a prescription to meet the needs of individual patients. May be customized. There is not a specific HCPCS billing code that describes our compounded formulations. For any questions regarding coding or billing, please contact the payor directly.

References: 1: Thompson IM; Tangen CM; Goodman PJ, et al. Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005;294(23) pgs 2996-3002.2: Johannes CB, Araujo AB, Feldman HA, et. al. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. The Journal of Urology. 2000 vol 163 (2), pgs 460-463. 3: American Urological Association. Available at http://www.auanet.org/education/guidelines/erectile-dysfunction. Accessed April 1, 2015.